Publications
- Present
Lines CL, McGrath MJ, Dorwart T, and Conn CS. The integrated stress response in cancer progression: a force for plasticity and resistance. Front. Oncol., Sec. Cancer Molecular Targets and Therapeutics. 2023 Aug 3:13:1206561. PMID: 37601686Zhang D, Li AM, Hu G, Huang M, Yang F, Zhang L, Wellen KE, Xu X, Conn CS, Zou W, Kahn M, Rhoades SD, Weljie AM, Fuchs SY, Amankulor N, Yoshor D, Ye J, Koumenis C, Gong Y, Fan Y. PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy. Cell Metab. 2023 Mar 7;35(3):517-534.e8. PMID: 36804058Chiu H, Buono R, Jackson LV, Herzog L, Mallya S, Conn CS, Ruggero D, and Fruman D. Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function. iScience. 2021 Jun 17;24(7):102748. PMID: 34278258*Conn CS, *Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBarardinis RJ, Burlingame AL, Ruggero D. The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity. Nature Metabolism. 2021 Feb; (3): 244–257. PMID: 33619378 * - Co-first° Press Release “Store Fat or Burn It? Targeting a Single Protein Flips the Switch”
° Recommended by Faculty 1000, 2021
2015-2019
Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salas Salinas C, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, and Koumenis C. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progression. Nat Cell Biol. 2019 Jul;21(7):889-899. doi: 10.1038/s41556-019-0347-9° Recommended by Faculty 1000, 2019
Wei J, Kishton RJ, Angel M, Conn CS, Dalla-Venezia N, Marcel V, Vincent A, Catez F, Ferré S, Ayadi L, Marchand V, Dersh D, Gibbs JS, Ivanov IP, Fridlyand N, Couté Y, Diaz JJ, Qian SB, Staudt LM, Restifo NP, Yewdell JW. Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance. Mol Cell. 2019 Jan 24. S1097-2765(18)31096-7²*Conn CS, *Nguyen HG, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D². Development of a stress response therapy targeting aggressive prostate cancer. Science Translational Med. 2018 May 2;10(439). PMID: 29720449 ² - Co-corresponding; * - Co-first° Press Release “Research Finds ‘Achilles Heel’ for Aggressive Prostate Cancer”
° Focus Cancer Article in Science Translational Medicine Issue 439
Gwinn DM, Lee AG, Briones-Martin-Del-Campo M, Conn CS, Simpson DR, Scott AI, Le A, Cowan TM, Ruggero D, Sweet-Cordero EA. Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer Cell. 2018 Jan 8;33(1):91-107.e6. PMID: 29316436° Recommended by Faculty 1000, February 2018
Truillet C, Cunningham JT, Parker MF, Huynh LT, Conn CS, Ruggero D, Lewis JS, Evans MJ. Non-invasive measurement of mTORC1 signaling with 89Zr-transferrin. Clin Cancer Res. 2016 Dec 22. pii: clincanres.2448.2016. PMID: 28007777
*Truitt ML, *Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D. Differential Requirements for eIF4E Dose in Normal Development and Cancer. Cell. 2015; 162(1):59-71. PMID: 26095252* -Authors contributed equally to this work° Press Release “Cancer Blocked by Halving Levels of Protein thought to be ‘Untouchable’” ° Recommended by Faculty 1000, September 2015
2011-2015
Zhang X, Gao X, Coots RA, Conn CS, Liu B, Qian SB. Translational control of the cytosolic stress response by mitochondrial ribosomal protein L18. Nat Struct Mol Biol. 2015; 22(5):404-10. PMID: 25866880° Editor's choice in Science Volume 348, Number 6239, June 2015
° News & Views in Nature Structural & Molecular Biology 22, 350–351, May 2015
Conn CS and Qian SB. Nutrient signaling in Protein Homeostasis: an increase in quantity at the expense of protein quality. Science Signaling 2013; 6(271):ra24. PMID: 23592839
° Editor's choice for Cell Biology in Science Volume 340, Number 6131, April 2013
° Recommended by Faculty 1000, May 2013
Liu B, Conn CS, and Qian SB. Viewing folding of nascent polypeptide chains from ribosomes. Expert Rev Proteomics 2012; 9(6):579-81. PMID: 23256666Conn CS and Qian SB. mTOR signaling in protein homeostasis: Less is more? Cell Cycle 2011; 10(12). PMID: 21555915*Sun J, *Conn CS, Han Y, Yeung V, Qian SB. PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation. J Biol Chem 2011; 286:6791-800. PMID: 21177857* - Authors contributed equally to this work